Company / Profit Margin
IONIS PHARMACEUTICALS INC Profit Margin History
FY2016-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Profit Margin
-40.4%
FY2025
5-year range
-200.3% / 63.2%
FY2021-FY2025
Trend
+79.8%
vs FY2024
Sector context
#87 of 145
Health Care
What the data says
At -40.4%, IONIS PHARMACEUTICALS INC's profit margin ranks #87 of 145 in the Health Care sector. Profit Margin has fluctuated over the past 10 years, ranging from -200.3% in FY2024 to 94.3% in FY2020.
Based on SEC 10-K filings.
-40.4% in FY2025 with a 5-year CAGR of -134.7%.
Improved from -112.9% to -40.4% over the past 2 years.
Health Care sector context is included.
Profit Margin over time
Growth rates
- 3-Year Change
- +137.2pp
- 5-Year Change
- -134.7pp
- 10-Year Change
- -
Sector benchmark
#87 of 145 in Health CareTop 60% of 145This company -40.4% Sector average -792.7%
▼
+94.9% above sector average
Key checks
Key Insights
- In FY2025, profit margin increased 79.8% year-over-year.
- Currently 752.3pp above the Health Care sector average.
- Peak profit margin was recorded in FY2020.
- Lowest profit margin in the period was in FY2024.
Company context
Key Data Points
- Altman Z-Score -0.18 (distress zone, below 1.8 threshold)
- High earnings quality (cash-backed earnings)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Profit MarginValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -40.4% | +79.8% |
| FY2024 | -200.3% | -77.5% |
| FY2023 | -112.9% | +36.4% |
| FY2022 | -177.6% | -380.9% |
| FY2021 | 63.2% | -33.0% |
| FY2020 | 94.3% | +134614.3% |
| FY2019 | 0.1% | +100.2% |
| FY2018 | -41.8% | -13590.3% |
| FY2017 | 0.3% | +101.8% |
| FY2016 | -17.4% | +44.0% |
As of FY2025 · SEC 10-K · Updated Jun 30, 2026