Company / Operating Margin
IONIS PHARMACEUTICALS INC Operating Margin History
FY2016-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Operating Margin
-40.5%
FY2025
5-year range
-270.1% / 83.2%
FY2021-FY2025
Trend
+80.7%
vs FY2024
Sector context
#76 of 135
Health Care
What the data says
At -40.5%, IONIS PHARMACEUTICALS INC's operating margin ranks #76 of 135 in the Health Care sector. Operating Margin has fluctuated over the past 10 years, ranging from -270.1% in FY2022 to 83.2% in FY2021.
Based on SEC 10-K filings.
-40.5% in FY2025 with a 5-year CAGR of -19.3%.
Improved from -109.0% to -40.5% over the past 2 years.
Health Care sector context is included.
Operating Margin over time
Growth rates
- 3-Year Change
- +229.6pp
- 5-Year Change
- -19.3pp
- 10-Year Change
- -
Sector benchmark
#76 of 135 in Health CareTop 56% of 135This company -40.5% Sector average -774.4%
▼
+94.8% above sector average
Key checks
Key Insights
- In FY2025, operating margin increased 80.7% year-over-year.
- Currently 734.0pp above the Health Care sector average.
- Peak operating margin was recorded in FY2021.
- Lowest operating margin in the period was in FY2022.
Company context
Key Data Points
- Altman Z-Score -0.18 (distress zone, below 1.8 threshold)
- High earnings quality (cash-backed earnings)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Operating MarginValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -40.5% | +80.7% |
| FY2024 | -209.7% | -92.3% |
| FY2023 | -109.0% | +59.6% |
| FY2022 | -270.1% | -424.8% |
| FY2021 | 83.2% | +493.3% |
| FY2020 | -21.1% | -436.1% |
| FY2019 | 6.3% | +145.1% |
| FY2018 | -14.0% | -149.6% |
| FY2017 | 28.1% | +583.7% |
| FY2016 | -5.8% | +78.2% |
As of FY2025 · SEC 10-K · Updated Jun 30, 2026