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IONIS PHARMACEUTICALS INC
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Financials

Company / Financials

IONIS PHARMACEUTICALS INC Financials

FY2016-FY2025 · Annual data · Source: SEC filings

At a glance

Latest annual filing available

Revenue

$943.7M

FY2025 · +316.5% YoY

Net Income

-$381.4M

FY2025 · +16.0% YoY

Profit Margin

-40.4%

FY2025 · net income / revenue

ROE

-78.0%

FY2025 · return on equity

Total Assets

$3.5B

FY2025

Total Debt

$1.8B

3.71x debt/equity

Equity

$489.1M

FY2025

ROA

-10.8%

FY2025 · return on assets

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Statement paths

Income StatementRevenue, expenses, margins, and profit.View Balance SheetAssets, debt, liabilities, and equity.View Cash Flow StatementCash generated, reinvested, and returned.View

Financial highlights

Key Data Points

Altman Z-Score -0.18 (distress zone, below 1.8 threshold)
High earnings quality (cash-backed earnings)

Data sourced from SEC EDGAR filings. Not investment advice.

Metric history

Revenue HistoryTotal revenue from operations$943.7M+316.5% YoY Net Income HistoryProfit after all expenses and taxes-$381.4M+16.0% YoY Cost of Revenue HistoryDirect costs of producing goods and services sold$15.9M+41.9% YoY Operating Income HistoryProfit from core business operations before interest and taxes-$381.7M+19.7% YoY SG&A Expense HistorySelling, general, and administrative expenses$393.9M+47.3% YoY R&D Expense HistoryResearch and development spending$915.6M+1.6% YoY Interest Expense HistoryCost of borrowing and debt obligations$17.3M+1.6% YoY Income Tax HistoryTotal income tax expense$1.8M+128.9% YoY EPS (Basic) HistoryBasic earnings per share-$2.56-34.7% YoY EPS (Diluted) HistoryDiluted earnings per share including stock options and convertibles-$2.56-34.7% YoY

Continue your research

Income StatementRevenue, expenses, margins, and profit.View Balance SheetAssets, debt, liabilities, and equity.View Cash Flow StatementCash generated, reinvested, and returned.View Financial RatiosMargin, return, leverage, and DuPont context.View Piotroski F-ScoreNine checks for profitability, leverage, and efficiency.View Altman Z-ScoreA bankruptcy-risk model built from financial statements.View

Data basis

10 annual filings shown

Primary company stock selected

SEC annual filings used as source

Financial data is for research and education. This is not investment advice.

Back to IONIS PHARMACEUTICALS INC overview

Data Sources

SEC 10-K Annual Filings

FY2025· Updated Jun 30, 2026

System data refreshed: Jun 30, 2026

For informational purposes only. Not investment advice. Past performance is not indicative of future results. Data sourced from SEC EDGAR filings. Consult a qualified financial advisor before making investment decisions.