Company / Operating Income
IONIS PHARMACEUTICALS INC Operating Income History
FY2016-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Operating Income
-$381.7M
FY2025
5-year range
-$475.1M / $365.9M
FY2021-FY2025
Trend
+19.7%
vs FY2024
Sector context
#174 of 204
Health Care
What the data says
IONIS PHARMACEUTICALS INC's operating income of -$382M is lower than 85% of companies in the Health Care sector (FY2025). Operating Income has fluctuated over the past 10 years, ranging from -$475M in FY2024 to $366M in FY2021.
Based on SEC 10-K filings.
-$382M in FY2025.
Declined from -$354M to -$382M over the past 2 years.
Health Care sector context is included.
Operating Income over time
Growth rates
- 3-Year CAGR
- -
- 5-Year CAGR
- -
- 10-Year CAGR
- -
Sector benchmark
Bottom 15% in Health CareTop 85% of 204This company -$381.7M Sector average $107.8M
▼
-454.2% below sector average
Key checks
Key Insights
- In FY2025, operating income increased 19.7% year-over-year.
- Ranks #174 out of 204 companies in the Health Care sector.
- Peak operating income was recorded in FY2021.
- Lowest operating income in the period was in FY2024.
Company context
Key Data Points
- Altman Z-Score -0.18 (distress zone, below 1.8 threshold)
- High earnings quality (cash-backed earnings)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Operating IncomeValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -$381.7M | +19.7% |
| FY2024 | -$475.1M | -34.3% |
| FY2023 | -$353.7M | +13.8% |
| FY2022 | -$410.2M | -212.1% |
| FY2021 | $365.9M | +696.2% |
| FY2020 | -$61.4M | -297.7% |
| FY2019 | $31.0M | +254.0% |
| FY2018 | -$20.2M | -164.9% |
| FY2017 | $31.0M | +254.0% |
| FY2016 | -$20.2M | +73.4% |
As of FY2025 · SEC 10-K · Updated Jun 30, 2026