Company / Operating Cash Flow
IONIS PHARMACEUTICALS INC Operating Cash Flow History
FY2016-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Operating Cash Flow
-$268.6M
FY2025
5-year range
-$500.9M / $345.6M
FY2021-FY2025
Trend
+46.4%
vs FY2024
Sector context
#185 of 216
Health Care
What the data says
IONIS PHARMACEUTICALS INC's operating cash flow of -$269M is lower than 86% of companies in the Health Care sector (FY2025). Operating Cash Flow returned to growth in FY2025 after 4 years of decline, reaching -$269M.
Based on SEC 10-K filings.
-$269M in FY2025.
Improved from -$308M to -$269M over the past 2 years.
Health Care sector context is included.
Operating Cash Flow over time
Growth rates
- 3-Year CAGR
- -
- 5-Year CAGR
- -
- 10-Year CAGR
- -
Sector benchmark
Bottom 14% in Health CareTop 86% of 216This company -$268.6M Sector average $659.0M
▼
-140.8% below sector average
Key checks
Key Insights
- In FY2025, operating cash flow increased 46.4% year-over-year.
- Ranks #185 out of 216 companies in the Health Care sector.
- Peak operating cash flow was recorded in FY2020.
- Lowest operating cash flow in the period was in FY2024.
Company context
Key Data Points
- Altman Z-Score -0.18 (distress zone, below 1.8 threshold)
- High earnings quality (cash-backed earnings)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Operating Cash FlowValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -$268.6M | +46.4% |
| FY2024 | -$500.9M | -62.9% |
| FY2023 | -$307.5M | -12.1% |
| FY2022 | -$274.4M | -179.4% |
| FY2021 | $345.6M | -42.7% |
| FY2020 | $602.9M | +246.2% |
| FY2019 | $174.1M | +255.3% |
| FY2018 | -$112.1M | -164.4% |
| FY2017 | $174.1M | +255.3% |
| FY2016 | -$112.1M | -630.7% |
As of FY2025 · SEC 10-K · Updated Jun 30, 2026