Company / Operating Income
Upstream Bio, Inc. Operating Income History
FY2023-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Operating Income
-$160.4M
FY2025
5-year range
-$160.4M / -$40.1M
FY2023-FY2025
Trend
-299.8%
vs FY2024
Sector context
#121 of 204
Health Care
What the data says
Operating Income changed -300% YoY in FY2025, a notable deviation from the 2-year average annual change of -150%.
Based on SEC 10-K filings.
-$160M in FY2025.
Declined from -$40M to -$160M over the past 2 years.
Health Care sector context is included.
Operating Income over time
Growth rates
- 3-Year CAGR
- -
- 5-Year CAGR
- -
- 10-Year CAGR
- -
Sector benchmark
#121 of 204 in Health CareTop 59% of 204This company -$160.4M Sector average $107.7M
▼
-248.9% below sector average
Key checks
Key Insights
- In FY2025, operating income decreased 299.8% year-over-year.
- Ranks #121 out of 204 companies in the Health Care sector.
Company context
Key Data Points
- Low Piotroski F-Score: 2/9 (multiple financial health concerns)
- Altman Z-Score 8.68 (safe zone, above 2.9 threshold)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Operating IncomeValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -$160.4M | -299.8% |
| FY2024 | -$40.1M | +0.0% |
| FY2023 | -$40.1M | - |
As of FY2025 · SEC 10-K · Updated Jun 30, 2026