Company / Operating Margin
Upstream Bio, Inc. Operating Margin History
FY2024-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Operating Margin
-5618.8%
FY2025
5-year range
-5618.8% / -1685.5%
FY2024-FY2025
Trend
-233.4%
vs FY2024
Sector context
#131 of 136
Health Care
What the data says
Among 136 Health Care companies, Upstream Bio, Inc. is in the bottom 4% for operating margin.
Based on SEC 10-K filings.
-5618.8% in FY2025.
Health Care sector context is included.
Operating Margin over time
Growth rates
- 3-Year Change
- -
- 5-Year Change
- -
- 10-Year Change
- -
Sector benchmark
Bottom 4% in Health CareTop 96% of 136This company -5618.8% Sector average -778.9%
▼
-621.3% below sector average
Key checks
Key Insights
- In FY2025, operating margin decreased 233.4% year-over-year.
- Currently 4839.9pp below the Health Care sector average.
Company context
Key Data Points
- Low Piotroski F-Score: 2/9 (multiple financial health concerns)
- Altman Z-Score 8.68 (safe zone, above 2.9 threshold)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Operating MarginValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -5618.8% | -233.4% |
| FY2024 | -1685.5% | - |
| FY2023 | - | - |
As of FY2025 · SEC 10-K · Updated Jun 30, 2026