Company / Profit Margin
Spero Therapeutics, Inc. Profit Margin History
FY2018-FY2025 · Annual data · Source: SEC filings
At a glance
Latest annual filing availableLatest Profit Margin
-142.9%
FY2025
5-year range
-839.2% / 22.0%
FY2021-FY2025
Trend
-750.2%
vs FY2024
Sector context
Sector data unavailable
Latest sector comparison
What the data says
Profit Margin changed -750% YoY in FY2025, a notable deviation from the 7-year average annual change of -71%.
Based on SEC 10-K filings.
-142.9% in FY2025 with a 5-year CAGR of +192.7%.
Declined from -86.7% to -142.9% over the past 2 years.
Profit Margin over time
Growth rates
- 3-Year Change
- +348.7pp
- 5-Year Change
- +192.7pp
- 10-Year Change
- -
Key checks
Key Insights
- In FY2025, profit margin decreased 750.2% year-over-year.
- Peak profit margin was recorded in FY2024.
- Lowest profit margin in the period was in FY2018.
Company context
Key Data Points
- Low Piotroski F-Score: 2/9 (multiple financial health concerns)
- Altman Z-Score -1.15 (distress zone, below 1.8 threshold)
- High earnings quality (cash-backed earnings)
Data sourced from SEC EDGAR filings. Not investment advice.
Annual data
| Year | Profit MarginValue | YoY GrowthYoY |
|---|---|---|
| FY2025 | -142.9% | -750.2% |
| FY2024 | 22.0% | +125.3% |
| FY2023 | -86.7% | +82.4% |
| FY2022 | -491.7% | +41.4% |
| FY2021 | -839.2% | -150.1% |
| FY2020 | -335.6% | +68.1% |
| FY2019 | -1051.4% | +86.2% |
| FY2018 | -7609.3% | - |
As of FY2025 · SEC 10-K · Updated Jun 28, 2026